LOSS OF P19(ARF) FACILITATES THE ANGIOGENIC SWITCH AND TUMOR INITIATION IN A MULTI-STAGE CANCER MODEL VIA P53-DEPENDENT AND INDEPENDENT MECHANISMS.

Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.

The Arf tumor suppressor acts as a sensor of oncogenic signals, countering aberrant proliferation in large part via activation of the p53 transcriptional program, though a number of p53-independent functions have been described.Mounting evidence suggests that, in addition to promoting tumorigenesis via disruptions in the homeostatic balance between

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Reconsidering the use of rankings in the valuation of health states: a model for estimating cardinal values from ordinal data

Abstract Background In survey studies on health-state valuations, ordinal ranking exercises often are used as precursors to other elicitation methods such as the time trade-off (TTO) or standard gamble, but the ranking data have not been used in deriving cardinal valuations.This study reconsiders the role of ordinal Sports Nutrition supplements ran

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Severity assessment of wheat stripe rust based on machine learning

IntroductionThe accurate severity assessment of wheat stripe rust is the basis for the pathogen-host interaction phenotyping, disease prediction, and disease control measure making.MethodsTo realize STEM CELL ACTIVATOR the rapid and accurate severity assessment of the disease, the severity assessment methods of the disease were investigated based o

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Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity

AbstractDoxorubicin (DOX), a commonly used anti-cancer drug, is limited by its cardiotoxicity and multidrug resistance (MDR) of tumor cells.Epigallocatechin gallate (EGCG), a natural antioxidant component, can effectively reduce the cardiotoxicity of DOX.Meanwhile, EGCG can inhibit the expression of P-glycoprotein (P-gp) and reverse the MDR of tumo

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